Musculoskeletal conditions affect over 100 million patients and cost approximately $661 billion annually, representing 8% of payers' medical expenditures. Current MSK care approaches are fragmented and overly reliant on imaging, opioids, and surgical interventions, leading to poor patient outcomes and financial strain. High-value care requires evidence-based, holistic treatment that meets patient needs without unnecessary resources, emphasizing physical therapy, lifestyle modifications, and digital health solutions. The healthcare industry must address misaligned payment incentives and traditional utilization management strategies that create barriers to delivering coordinated, cost-effective care.