Organizations face unprecedented supply chain challenges as new tariff implementations and geopolitical volatility create interconnected risks across strategic, operational, financial, cyber, compliance, and reputational domains. With 83% of risk professionals reporting that interconnected risks are emerging at a more rapid pace than before, and 63% of businesses experiencing higher-than-expected supply chain losses despite enhanced risk management efforts, enterprise risk management (ERM) has become critical for navigating these complexities. This guide explores how ERM functions can provide holistic visibility and connect the dots between various risk domains, offering proactive strategies including regular risk calibration exercises, scenario planning, and real-time monitoring to build supply chain resilience. By implementing structured ERM approaches, organizations can better identify, escalate, and respond to emerging supply chain risks with the agility and speed required in today's turbulent global market.