Data centers operate in a high-stakes environment where a single unmanaged cable or missing lockout tag can result in life-altering injuries and costly downtime. To protect personnel and maintain the 99.999% uptime standard the industry demands, OSHA-compliant safety protocols must be embedded directly into daily workflows and facility infrastructure. Three critical areas require focused attention: hazardous energy control through lockout tagout (LOTO) procedures, structured cable management to eliminate trip hazards and thermal risks, and clear visual communication via floor markings and standardized signage. The most effective approach is proactive planning during the construction phase, ensuring safety is built into the blueprint rather than retrofitted at greater expense.