Burnout is at a critical level, with 58% of workers identifying their job as the main source of their mental health challenges, and millions leaving their roles as part of the Great Resignation. Organizations must go beyond treating symptoms and address the root cause: the culture around how work gets done. Employee well-being is shaped by four key drivers — alignment, support, resilience, and a fourth factor — all of which hinge on balancing workplace demands with adequate resources. When demands consistently outpace resources, the result is absenteeism, disengagement, poor performance, and deteriorating physical and mental health. Real change requires a collective commitment from organizations, leaders, and employees alike.